Our Applications
We are continually working with clients to develop a wide range of additional applications including perfusion and micro-carrier separation.
Harvest clarification
kSep® Systems are the first single-use centrifugation systems that are completely closed. These systems are fully-automated and designed to recover >97% of product by efficient product displacement from slurry. In addition, low-shear process ensures reduced downstream contaminiation (due to cellular debris or proteolytic enzymes) and high product quality. This is the only scalable technology capable of efficiently handling high cell density cultures (10-50 x 106 cells/mL).
Concentrate-Wash-Harvest
kSep® centrifuges offer the benefit of concentrating cells, while maintaining high recovery and viability. Additionally, these systems remove cell debris and light particulate impurities (e.g. plastic particles from single use plastic products), while significantly reducing any aggregation of cells. kSep® Systems do not contain any rotary seals (therefore they operate as a truly closed system) or filters (therefore they operate without clogging). These features are critical for cell therapy manufacturing.
Once captured and concentrated, the cells can be efficiently washed, manipulated, and harvested. This technology is a breakthrough for applications requiring maintenance of cellular integrity during processing. This automated sequence is currently being used for cell therapy manufacturing, cell banking, and vaccine manufacturing processes.
